Standardizing the d-dimer Assay: Proposing the d-dimer International Managed Ratio

D Dimer Assay

Introduction A new test for determination of circulating fibrin degradation products has recently been marketed in the U.S. Known genericaUy as the D-dimer assay, it is a direct latex agglutination assay employing monoclonal anubody specific for digestion products of crosslinked fibrin. It is offered as an alternative to or replacement for the widely available Thrombo-Wellcotest assay for fibri...

The clinical use of a D-dimer assay

Comparing D-dimer assays

• Including many patients with elevated D-dimer concentrations due to other causes than VTE may give a false increase in sensitivity and negative predictive value • The prevalence of VTE has an influence on the predictive values – higher prevalence gives lower NPV • A high ratio of proximal to distal DVT will increase both the sensitivity and the negative predictive value • A study focused on P...

The Effect of Preanalytical, Analytical, and Postanalytical Variables on D-dimer Measurement

D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of activation of coagulation and fibrinolysis, and it is routinely used for ruling out venous thromboembolism (VTE). D-dimer is increasingly used to assess the risk of VTE recurrence and to help define the uoptimal duration of anticoa...

Widely Used Types and Clinical Applications of D-Dimer Assay.

D-dimers are formed by the breakdown of fibrinogen and fibrin during fibrinolysis. D-dimer analysis is critical for the diagnosis of deep vein thrombosis, pulmonary embolism, and disseminated intravascular coagulation. Modern assays for D-dimer are monoclonal antibody based. The enzyme-linked immunosorbent assay (ELISA) is the reference method for D-dimer analysis in the central clinical labora...